Internal Medicine
How a New Urgency Score Reforms Donor Heart Allocation
Discover how the new US Candidate Risk Score improves donor heart allocation by prioritizing objective laboratory metrics over device-based listing tiers.
Mastering Delirium Management in Hospitalized Patients
Explore evidence-based delirium management strategies, identifying risk factors, pathophysiology, and practical multicomponent prevention protocols.
How Should You Screen a 26-Year-Old for Cervical Cancer?
Explore modern cervical cancer screening strategies for young adults, comparing cytology, primary HPV testing, and emerging self-collection guidelines.
Are Benzodiazepines Truly Safe During Early Pregnancy?
A large cohort study finds that first-trimester benzodiazepine use in pregnancy does not substantially raise the overall risk of major congenital defects.
Can Optogenetic Therapy Restore Sight in Blind Patients?
Optogenetic therapy combined with light goggles safely restores light sensitivity in advanced retinitis pigmentosa, according to a recent clinical trial.
Obinutuzumab vs Tacrolimus in Membranous Nephropathy
The MAJESTY trial shows obinutuzumab achieves superior complete remission rates over tacrolimus in primary membranous nephropathy at 104 weeks of therapy.
Sodium Bicarbonate Fails to Improve Cardiac Arrest ROSC
The BIHCA trial reveals that sodium bicarbonate cardiac arrest therapy does not improve sustained ROSC rates and raises risks of alkalosis and hypernatremia.
Does Sodium Bicarbonate Help in Cardiac Arrest Trials?
A randomized trial shows sodium bicarbonate cardiac arrest use fails to improve sustained ROSC, survival, or neurological recovery in hospitalized adults.
Lean MASLD: Histologic Severity and Prognostic Outcomes
Discover key insights on lean MASLD histology, noninvasive test accuracy, and clinical outcomes from a global cohort of over 18,000 patients.
Giredestrant Plus Everolimus Halts ER+ Breast Cancer
Oral giredestrant plus everolimus significantly improves progression-free survival in patients with ER-positive advanced breast cancer after CDK4/6 inhibitors.
Is Supervised Exercise the Key to Lasting ACL Recovery?
Discover how supervised exercise therapy improves knee pain and function in young adults after ACL reconstruction, based on the landmark SUPER-Knee trial.
Anito-cel Yields Durable Responses in Multiple Myeloma
Discover phase 1 trial results of anito-cel in multiple myeloma. The novel ddBCMA CAR T-cell therapy showed a 100% response rate with low neurotoxicity.
Etuvetidigene Autotemcel Shows Lasting Benefit in WAS
Etuvetidigene autotemcel offers sustained clinical efficacy and reduces severe infections and bleeding in patients with Wiskott-Aldrich syndrome.
Can Polygenic Risk Scores Transform Daily Patient Care?
Explore how polygenic risk scores and pharmacogenomics may translate genomic data into routine clinical practice for common adult-onset diseases.
How Cancer Vaccines Are Revolutionizing Tumor Therapy
Explore how modern cancer vaccines activate adaptive immunity against tumors, leveraging neoantigens and novel delivery systems to improve patient outcomes.
New 2026 Guidelines Transform Modern Tobacco Cessation
Discover updated tobacco use treatment guidelines featuring varenicline, combination NRT, and motivational interviewing to boost quit rates.
Intrauterine Mepivacaine Cuts IUD Insertion Pain in RCT
Intrauterine mepivacaine instillation significantly reduces pain during IUD insertion in nulliparous individuals, according to a randomized clinical trial.
Can 7 Days of Antibiotics Cure Bone and Joint Infection?
The SOLARIO trial shows short-course orthopedic infection antibiotics match long regimens in efficacy while drastically cutting adverse treatment symptoms.
Can We Safely Extend Colonoscopy Intervals to 5 Years?
The EPoS II trial shows 5-year surveillance colonoscopy intervals are noninferior to 3-year visits for patients with high-risk colorectal adenomas.
Can Blinatumomab Safely Replace Intensive Chemotherapy?
Explore how blinatumomab in pediatric ALL replaces chemotherapy, improving event-free survival to 83% while significantly lowering severe infection risks.
Does Maternal Egg and Peanut Intake Stop Baby Allergies?
Discover findings from the PrEggNut trial on infant allergy prevention and whether high maternal egg and peanut consumption during pregnancy protects infants.
Esophageal Cancer: Modern Clinical Insights and Care
Explore recent updates on esophageal cancer epidemiology, histological distinctions, clinical presentation, and multimodal management strategies for clinicians.
2025 VA/DoD Lipid Guidelines: Key Updates for Practice
Discover the 2025 VA/DoD lipid management guidelines synopsis, featuring PREVENT risk scoring, Lp(a) testing, and intensive ASCVD combination regimens.
KDIGO 2026 Updates: Better Management of Anemia in CKD
Discover the KDIGO 2026 guidelines on anemia in CKD, featuring revised hemoglobin targets, iron therapy protocols, and optimal first-line ESA usage.
LAIS Trial: Can Loberamisal Transform Stroke Recovery?
Explore findings from the LAIS trial on loberamisal in acute stroke, showing enhanced 90-day functional recovery and safety within 48 hours of onset.
Severe Methemoglobinemia Outbreak: Fuel Toxicity Alert
Learn about severe methemoglobinemia caused by fuel additives, key diagnostic signs, methylene blue dosing, and risks of delayed hemolytic anemia.
Modern Multiple Myeloma Care: Trials to Clinical Practice
Explore modern multiple myeloma treatment strategies, from quadruplet induction and stem cell transplant to CAR T-cell sequencing and MRD testing.
Tuberculosis Today: A Step-by-Step Practical Care Guide
Explore evidence-based tuberculosis diagnosis and treatment guidelines, screening strategies, molecular assays, and therapeutic regimens for clinical care.
Optimal Hemoglobin Levels: Is Borderline Normal Safe?
A prospective UK Biobank study links blood hemoglobin concentration to mortality risk, revealing surprising risks in borderline normal clinical ranges.
Improving Discharge Transitions in Alcohol Use Disorder
A systematic review assesses hospital-based strategies to improve outpatient alcohol use disorder follow-up, revealing promising multi-component models.
Can Tozorakimab Prevent Persistent COPD Exacerbations?
Phase 3 OBERON and TITANIA trials show tozorakimab reduces COPD exacerbations across smoking statuses and eosinophil counts.
Mastering Tuberculosis Care: Modern Diagnostic Pathways
Explore modern tuberculosis management, rapid molecular diagnostics, and evidence-based treatment regimens to optimize outcomes in high-burden settings.
Borderline Hemoglobin Levels and Mortality: New Evidence
Discover new data on hemoglobin concentration and mortality. See why borderline anemia and elevated hemoglobin increase long-term mortality risk.
Can Inpatient Strategies Boost Alcohol Care Linkage?
Hospital discharge interventions for alcohol use disorder improve outpatient linkage when combining medications, behavioral care, and coordination.
Navigating Pulmonary Nodules: Evidence-Based Management
Master pulmonary nodule management with evidence-based guidance. Learn how to assess malignancy risk, monitor stability, and select biopsies.
NOAC vs ASA: Breakthrough Findings in Post-TAVI Care
Explore the ACASA-TAVI trial findings comparing NOAC and ASA monotherapy for leaflet thrombosis prevention and long-term safety after TAVI.
REVEAL Study: Accurate Diagnosis of Cardiac Amyloidosis
The REVEAL trial demonstrates high sensitivity and specificity for cardiac amyloidosis PET CT imaging using 124I-evuzamitide in suspected heart disease.
Gene Silencer Therapy Cuts Mortality in ATTR-CM Patients
Discover new phase 3 meta-analysis insights on gene silencer therapy for ATTR-CM, highlighting mortality reduction and combination treatment effects.
Low-Voltage Zone Ablation for Persistent AF: Trial Data
Explore the IDEAL-AF trial findings on low-voltage zone ablation for persistent atrial fibrillation to improve rhythm control and clinical outcomes.
Does Evolocumab Before PCI Improve Acute MI Outcomes?
Administering evolocumab before PCI rapidly lowers LDL-C levels in acute MI patients, according to new 1-year findings from the AMUNDSEN clinical trial.
Does Posterior Wall Isolation Improve PFA in Persistent AF?
The PIFPAF-PFA trial evaluated whether adding posterior wall isolation to pulsed field ablation improves persistent AF outcomes.
Can Digital Outreach Strategies Improve Statin Adherence?
Discover how adaptive digital outreach improves statin adherence in high-risk ASCVD patients, based on findings from the ADHERE-ASCVD randomized clinical trial.
Aficamten Shows Major Promise for Nonobstructive HCM
Discover how aficamten improves exercise capacity and quality of life in nonobstructive hypertrophic cardiomyopathy based on ACACIA-HCM trial findings.
Can Tailored Antibiotics Shorten Endocarditis Therapy?
The POET-II trial reveals that response-tailored antibiotic therapy safely shortens infective endocarditis treatment duration in clinically stable adults.
AI-ECG System Detects Transthyretin Amyloid Cardiomyopathy
Discover how deep learning AI applied to routine ECGs enables rapid transthyretin amyloid cardiomyopathy screening and prioritizes advanced imaging.
2025 Adult Obesity Guidelines: Modern Care & GLP-1 Use
Discover the 2025 adult obesity management guideline updates, featuring revised screening cutoffs, GLP-1 therapies, and long-term treatment strategies.
Modern Adult Obesity Management: New VA/DoD Guidelines
Discover the updated 2025 VA/DoD clinical guidelines for adult obesity management, highlighting flexible pharmacotherapy and comprehensive lifestyle care.
Daily Zinc Cuts Infection Risk in Pediatric Sickle Cell
Explore findings from the ZIPS-2 trial showing daily zinc supplementation reduces infection rates in young children with sickle cell anemia.
STArT Trial: Does IV Arginine Shorten Sickle Cell Pain?
STArT trial finds IV arginine does not reduce time to crisis resolution or opioid use in pediatric sickle cell disease acute pain episodes. Read key findings.
Targeted Therapies in Myeloproliferative Neoplasms
Explore the genetic drivers, clonal evolution, and targeted therapies in myeloproliferative neoplasms to optimize long-term patient outcomes.